What is XENICAL?
is an oral prescription weight loss medication used to help
obese people lose weight and keep this weight off. XENICAL
works in your intestines, where it blocks some of the fat
you eat from being absorbed. This undigested fat is then eliminated
in your bowel movements. XENICAL should be used together with
a reduced-calorie diet that your doctor will recommend.
weight has been proven to contribute to an increased risk
of developing many medical problems, including high blood
pressure, high cholesterol, heart disease, and diabetes. The
consumption of excess fatty food and calories plays a significant
role in the development of excess weight. While fat is an
important component of a balanced diet, the consumption of
excess fat contributes to excess body weight, since fat provides
twice the number of calories per gram of weight as carbohydrates
and protein. Reduction of dietary fat intake is one potential
way of losing weight.
does XENICAL work?
you eat an excess amount of fat or calories, the excess is
stored as fat by the body resulting in weight gain. When you
eat fat, your body breaks it down into its simplest components
so that it can be absorbed. Enzymes in your intestinal tract,
called lipases, help digest (or breakdown) fat. When you take
XENICAL with meals, XENICAL attaches to the lipases and blocks
them from breaking down some of the fat you have eaten. The
undigested fat cannot be absorbed and is eliminated in your
bowel movements. By working this way, XENICAL helps block
about 30% of the fat eaten in food from being absorbed by
one year of treatment, XENICAL in combination with diet was
shown to be more effective in reducing weight than diet alone.
In most cases, weight loss was gradual. Patients treated with
XENICAL and a reduced-calorie diet for one year lost an average
of 13.4 pounds while those on a reduced-calorie diet alone
lost 5.8 pounds.
should use XENICAL?
weight loss program that includes a reduced-calorie diet and
appropriate physical activity may be adequate in some patients.
You should discuss with your doctor or other health care provider
whether XENICAL should be added to such a program.
may be right for you if you are considerably overweight (at
least 30% above ideal weight or a body mass index of 30 or
greater). XENICAL may also be right for you if you are overweight
(at least 20% above ideal weight or a body mass index of 27
or greater) and also have other risk factors such as high
blood pressure, high cholesterol, heart disease, or diabetes.
to determine your body mass index (BMI):
chart below illustrates BMI according to a variety of weights
and heights. The BMI is calculated by dividing your weight
in kilograms by your height in meters squared. To use this
the height closest to your height in the left-hand column.
Then move across the top row to find the weight closest to
The number where these two meet is your BMI. (For example,
a person who weighs 180 lbs and is 5'5" would have a
BMI of 30.)
should not use XENICAL?
have problems absorbing food (chronic malabsorption); or
have gallbladder problems; or
are pregnant or are breastfeeding a child; or
have ever had an allergic reaction to orlistat or any of the
inactive ingredients in XENICAL.
should I tell my doctor before taking XENICAL?
beginning treatment with XENICAL, make sure your doctor knows
if you are:
to any medicines, foods, or dyes;
taking any other weight-loss medication;
taking any other medicines (including those not prescribed
by your doctor);
taking any dietary supplements, including herbal products;
planning to become pregnant; or
anorexic or bulimic.
information will help you and your physician decide if the
expected advantages of XENICAL are greater than any possible
should I take XENICAL?
recommended dose is one 120 mg capsule by mouth with liquid
at each main meal that contains fat. You can take XENICAL
in conjunction with a mildly reduced-calorie diet up to 3
times a day. Each time you take XENICAL, your meal should
contain no more than about 30% of calories from fat. Take
XENICAL during meals or up to one hour after a meal. If you
occasionally miss a meal or have a meal without fat, you can
omit your dose of XENICAL. Doses greater than 120 mg three
times a day have not been shown to provide an additional weight
should use XENICAL together with a nutritionally balanced,
mildly reduced-calorie diet that contains no more than about
30% of calories from fat. You should evenly divide your daily
intake of fat, carbohydrates, and protein over 3 main meals.
should try to follow a healthy eating plan such as the one
developed by the American Heart Association. Following this
eating plan will help you lose weight while decreasing some
of the possible gastrointestinal effects you may experience
while taking XENICAL.
I take XENICAL while taking other medications?
sure to discuss with your doctor all medications (including
herbal products) you are currently taking, including medicines
you can get without a prescription (over-the-counter), to
determine if XENICAL can be taken in addition to these medications.
If you are taking cyclosporine, XENICAL and cyclosporine should
be taken at least 2 hours apart. If your cyclosporine levels
are being measured, more frequent monitoring may be necessary.
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